ISSN: 2459-1777 | E-ISSN 2587-0394
Volume : 9 Issue : 2 Year : 2024
Evaluation of Aqueous Flare in Graves’ Ophthalmopathy and its Relationship with Thyroid Hormones, Antibodies, and Clinical Activity Score [Beyoglu Eye J]
Beyoglu Eye J. 2023; 8(3): 208-213 | DOI: 10.14744/bej.2023.80557

Evaluation of Aqueous Flare in Graves’ Ophthalmopathy and its Relationship with Thyroid Hormones, Antibodies, and Clinical Activity Score

Hüsna Topçu1, Burcu Kemer Atik1, Berru Yargı Özkoçak1, Ayşe Çetin Efe1, Mehmet Göksel Ulaş1, Kübra Şerefoğlu Çabuk2
1University of Health Sciences, Beyoglu Eye Training and Research Hospital, Istanbul, Türkiye
2University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Istanbul, Türkiye

OBJECTIVES: The aim of this study was to assess intraocular inflammation in patients with active and inactive Graves’ ophthalmopathy (GO) using an aqueous laser flash meter and to assess its relationship with thyroid hormones, antibodies, and clinical activity score (CAS).
METHODS: Forty patients (29 females and 11 males) were included in the study. The patients were divided into two groups according to CAS; patients with CAS <3 (inactive) were included in Group 1 and patients with CAS ≥3 (active) were included in Group 2. The laser flare meter was used to measure the flare of aqueous humor. Each patient’s ocular findings, thyroid hormone, and antibody levels were also recorded.
RESULTS: The mean age of patients was 46.88±11.79 years in Group 1 and 44.50±12.59 years in Group 2 (p=0.555). The mean CAS was 0.88±0.65 in Group 1 and 3.57±0.85 in Group 2 (p<0.001). The mean aqueous flare was 6.5±2.2 ph/ms in Group 1 and 7.0±6.4 ph/ms in Group 2 (p=0.73). Hertel exophthalmometry, intraocular pressure (IOP), antithyroglobulin antibody, and thyroid stimulating hormone receptor antibody (TRAb) levels were similar in both groups (each p>0.05). There was no correlation between aqueous flare value and CAS, Hertel exophthalmometry, IOP, thyroid hormone, and antibody levels (each p>0.05). There was a significant correlation between CAS and antibody levels (each p<0.05).
DISCUSSION AND CONCLUSION: Flare values that are not much above the normal range may be an indication that intraocular inflammation is not elevated in GO patients. This suggests that the damage to the blood-aqueous barrier in these patients is not severe enough to increase intraocular inflammation.

Keywords: Aqueous flare, blood-aqueous barrier, clinical activity score, graves’ ophthalmopathy, laser flare photometry, thyroid stimulating hormone receptor antibody

Hüsna Topçu, Burcu Kemer Atik, Berru Yargı Özkoçak, Ayşe Çetin Efe, Mehmet Göksel Ulaş, Kübra Şerefoğlu Çabuk. Evaluation of Aqueous Flare in Graves’ Ophthalmopathy and its Relationship with Thyroid Hormones, Antibodies, and Clinical Activity Score. Beyoglu Eye J. 2023; 8(3): 208-213

Corresponding Author: Hüsna Topçu, Türkiye
Manuscript Language: English
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