ISSN: 2459 - 1777 | E-ISSN 2587-0394
Volume : 6 Issue : 2 Year : 2021

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Effects of Intravitreal Injection on Ocular Surface and Anterior Segment Parameters [Beyoglu Eye J]
Beyoglu Eye J. 2021; 6(2): 84-89 | DOI: 10.14744/bej.2021.65487

Effects of Intravitreal Injection on Ocular Surface and Anterior Segment Parameters

Hafize Gökben Ulutaş, Neslihan Parmak Yener
Department of Opthalmology, University of Health Sciences Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey

INTRODUCTION: This study was designed to investigate the long-term effects of intravitreal anti-vascular endothelial growth factor (VEGF) injections on ocular surface and anterior segment parameters. A comparison was performed of the treated eye and the fellow healthy eye.
METHODS: The study group included patients who had received at least 3 intravitreal injections of anti-VEGF agents (bevacizumab, ranibizumab, or aflibercept) for retinal vascular disorders. All of the subjects were treated in only 1 eye. A complete ophthalmological examination, including evaluation of tear break-up time (TBUT), the Schirmer 1 test, the Oxford Grading Scale, and the Ocular Surface Disease Index (OSDI) questionnaire, corneal topography, and specular microscopy were performed in both eyes 1 month after the last injection.
RESULTS: In this study, 49 eyes of 49 patients who underwent regular intravitreal injection in 1 eye were enrolled. The mean age was 63.85±9.8 years (range: 29-86 years). A mean of 4.06±1.7 (range: 3-11) injections were administered. There was no significant difference in the intraocular pressure, TBUT, Schirmer 1, fluorescein staining, or specular microscopy parameters (p>0.05). The mean non-invasive TBUT first and average values; the central, thinnest, and apex corneal thickness measurements; the anterior chamber depth, irido-corneal angle, corneal volume, and keratometry values were similar in each individual (p>0.05 for all parameters). The mean OSDI score was 27.5±17.6 for the injected eyes and 15.9±12.9 for the non-injected eyes (p<0.0001).
DISCUSSION AND CONCLUSION: Intravitreal anti-VEGF injections had no effect on ocular surface, corneal endothe-lium, and anterior segment parameters.

Keywords: Anterior segment, cornea, corneal topography, intravitreal injection, ocular surface

Hafize Gökben Ulutaş, Neslihan Parmak Yener. Effects of Intravitreal Injection on Ocular Surface and Anterior Segment Parameters. Beyoglu Eye J. 2021; 6(2): 84-89

Corresponding Author: Hafize Gökben Ulutaş, Türkiye
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