ISSN: 2459 - 1777 | E-ISSN 2587-0394
Volume : 5 Issue : 3 Year : 2020

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Beyoglu Eye Journal Carvacrol Protects Against Paclitaxel-Induced Retinal and Optic Nerve Cytotoxicity: A Histopathological Study [Beyoglu Eye J]
Beyoglu Eye J. 2020; 5(3): 219-222 | DOI: 10.14744/bej.2020.63825

Carvacrol Protects Against Paclitaxel-Induced Retinal and Optic Nerve Cytotoxicity: A Histopathological Study

Emine Çinici1, Nilay Dilekmen2, Zerrin Kutlu3, Büşra Dinçer4, Özkan Çinici5, Hilal Balta6, İlknur Çalık6
1Department of Eye Disease, Ataturk University, Erzurum, Turkey
2Department of Ophtalmology, Palandoken State Hospital, Erzurum, Turkey
3Department of Biochemistry, Ataturk University Faculty of Pharmacy, Erzurum, Turkey
4Department of Pharmacology, Erzincan Binali Yildirim University Faculty of Pharmacy, Erzincan, Turkey
5Department of Internal Medicine, Regional Training and Research Hospital, Erzurum, Turkey
6Department of Pathology, Regional Training and Research Hospital, Erzurum, Turkey

INTRODUCTION: Carvacrol (CV) is a phenolic monoterpenoid found in the essential oil of a number of aromatic plants and herbs. The present study was an investigation of the potential protective effect of CV against paclitaxel (PTX)-induced retinal and optic nerve cytotoxicity in rats.
METHODS: A total of 18 adult male Wistar albino rats (250-400g) were randomized into 3 equal groups comprising 6 animals each. Group 1 (control group) received intraperitoneal (IP) saline solution (0.5 mL/200 g) weekly for 4 weeks. Group 2 received an IP dose of PTX (5 mg/kg), and Group 3 received CV (25 mg/kg) 30 minutes after an IP dose of PTX (5 mg/kg) weekly for 4 weeks. At the conclusion of the experimental period, the retinal and optic nerve tissues of the subjects were evaluated histopathologically.

RESULTS: All of the retinal specimens in Group 1 (control) were histopathologically normal. In Group 2 (PTX), all of the eyes (6/6) revealed increased retinal vascularity and rosette-like structures in the outer nuclear layer, and in Group 3 (PTX-CV), all of the eyes (6/6) demonstrated normal retinal vascularity and the absence of rosette-like structures. All of the optic nerve specimens in Group 1 (control) were histopathologically normal. In Group 2 (PTX), all of the eyes (6/6) demonstrated severe vacuolization and a decreased number of astrocytes and oligodendrocytes in the optic nerve specimens, while 3 eyes (3/6) showed marked single cell necrosis. None of the eyes in Group 3 (PTX-CV) demonstrated either vacuolization or a reduction in the number of astrocytes and oligodendrocytes. No remarkable single cell necrosis was observed in the optic nerve specimens of Group 3 (PTX-CV).

DISCUSSION AND CONCLUSION: The histopathological findings indicated that CV played a protective role against PTX-induced cytotoxicity. CV might be a promising resource to counteract oxidative stress-based cytotoxicity in the field of retinal and optic nerve disorders.

Keywords: Antioxidant, carvacrol, oxidative stress, paclitaxel, paclitaxel-induced cytotoxicity.

Emine Çinici, Nilay Dilekmen, Zerrin Kutlu, Büşra Dinçer, Özkan Çinici, Hilal Balta, İlknur Çalık. Carvacrol Protects Against Paclitaxel-Induced Retinal and Optic Nerve Cytotoxicity: A Histopathological Study. Beyoglu Eye J. 2020; 5(3): 219-222

Corresponding Author: Emine Çinici, Türkiye
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