INTRODUCTION: To compare pupil diameters in light and dark after 0.15% brimonidine drops
in eyes with and without pseudoexfoliation syndrome (PES).
METHODS: Forty eyes of 40 patients who were applied 0.15% brimonidine to their right
eyes between March 2019 and June 2019 were included in the study. Study groups
included 20 subjects without PES (Group 1) and 20 patients with PES (Group 2).
Pupillary diameters before and after 30 minutes and 90 minutes after the application of
drops were recorded and analyzed.
RESULTS: The mean pupil diameters before drop application in Group 1 were 4.8 ± 1.2
mm in the light and 5.8 ± 1.2 mm in the dark. The mean pupil diameters before drop
application in Group 2 were 4.4 ± 1.2 mm; 4.9 ± 1.3 mm in the dark. At the 30th minute
after drop application, pupil diameters in light and dark were found as 4.3 ± 1.1 mm
and 5.3 ± 1.0 mm in Group 1, and 4.1 ± 1.1 mm and 4.5 ± 1 mm in Group 2,
respectively. Mean pupil diameters at the 90th minute were 4.2 ± 1.1 mm and 5.1 ± 1.1
mm in light and dark in Group 1, respectively. In Group 2, they were 4.0 ± 1.1 mm and
4.4 ± 1.2 mm. In the measurements at the dark before drop application, pupil
diameters in Group 2 were significantly lower than those in Group 1 (p≤0.05).
DISCUSSION AND CONCLUSION: Brimonidine makes significant miosis in eyes with PES compared to
normal eyes without PES. It may have positive effects on spherical aberrations, glare,
and halo. However, it should be kept in mind that inadequate pupillary dilatation due to
drop may make more difficult the cataract surgery and increase complication rate