INTRODUCTION: Thiol-disulfide balance is of great importance in some cellular events such as apoptosis and oxidative stress. In this study, we compared plasma thiol disulfide balance in patients with pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG).
METHODS: Thirty-one patients with PEXS, 43 patients with PEXG and 38 healthy controls were included in this prospective study. Plasma native thiol and disulfide levels were measured using a spectrophotometric assay and native thiol/disulfide ratio was analyzed.
RESULTS: Demographic characteristics were similar in three groups (p> 0.05). Statistically significant differences were observed in plasma disulfide levels (21.6 ± 7.3 vs. 17.4 ± 6.8) and native thiol/disulfide ratio (22.9 ± 9.1 vs. 29.9 ± 14.7) between PEXG and controls (p= 0.03; p= 0.02, respectively).
DISCUSSION AND CONCLUSION: Significant differences in plasma disulfide levels and native thiol/disulfide ratio in PEXG indicate the breakdown of the thiol- disulfide circuits.