ISSN: 2459 - 1777 | E-ISSN 2587-0394
Volume : Issue : Year : 2020

Quick Search




Beyoglu Eye Journal Assessment of Plasma Thiol-disulfide Balance in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma [Beyoglu Eye J]
Beyoglu Eye J. 2020; 5(3): 214-218 | DOI: 10.14744/bej.2020.41275

Assessment of Plasma Thiol-disulfide Balance in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Tamer Takmaz1, Derya Yaman2, Nilay Yuksel1, Mücella Arıkan Yorgun1, Almila Şenat3, Özcan Erel4
1Department of Ophthalmology, Ankara City Hospital, Ankara, Turkey
2Department of Ophthalmology, Kağızman State Hospital, Kars, Turkey
3Department of Medical Biochemistry, Taksim Training and Research Hospital,Istanbul, Turkey
4Department of Medical Biochemistry, Ankara City Hospital, Ankara, Turkey

INTRODUCTION: The thiol-disulfide balance is very important in cellular events such as apoptosis and oxidative stress. This study is a comparison of plasma thiol-disulfide homeostasis in patients with pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG).
METHODS: Thirty-one patients with PEXS, 43 patients with PEXG, and 38 healthy controls were included in this prospective study. The plasma level of native thiol and disulfide were measured using a spectrophotometric assay and the native thiol/disulfide ratio was analyzed
RESULTS: The demographic characteristics of the 3 groups were similar (p>0.05). Statistically significant differences were observed in the plasma disulfide levels (21.6±7.3 µmol/L vs. 17.4±6.8 µmol/L) and the native thiol/disulfide ratio (22.9±9.1 vs. 29.9±14.7) between the PEXG group and the controls (p=0.03, p=0.02, respectively).
DISCUSSION AND CONCLUSION: Significant differences in the plasma levels of disulfide and the native thiol/disulfide ratio in PEXG patients indicated a breakdown of the thiol-disulfide circuits.

Keywords: Oxidative stress, pseudoexfoliation syndrome, pseudoexfoliation glaucoma, thiol-disulfide balance.

Tamer Takmaz, Derya Yaman, Nilay Yuksel, Mücella Arıkan Yorgun, Almila Şenat, Özcan Erel. Assessment of Plasma Thiol-disulfide Balance in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma. Beyoglu Eye J. 2020; 5(3): 214-218

Corresponding Author: Tamer Takmaz, Türkiye
LookUs & Online Makale