ISSN: 2459 - 1777 | E-ISSN 2587-0394
Volume : 6 Issue : 4 Year : 2021

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Beyoglu Eye Journal Is There a Relationship between Statin Use and Corneal Specular Microscopy and Topography Findings? [Beyoglu Eye J]
Beyoglu Eye J. 2021; 6(4): 280-284 | DOI: 10.14744/bej.2021.28190

Is There a Relationship between Statin Use and Corneal Specular Microscopy and Topography Findings?

Bengi Ece Kurtul1, Alparslan Kurtul2, Kustharbek Ergashev3
1Department of Ophthalmology, Mustafa Kemal University Tayfur Ata Sökmen Faculty of Medicine, Hatay, Turkey
2Department of Cardiology, Mustafa Kemal University Tayfur Ata Sökmen Faculty of Medicine, Hatay, Turkey
3Department of Ophthalmology, Aritmi Osmangazi Hospital, Bursa, Turkey

INTRODUCTION: Information about the possible effect of statins on the human corneal endothelium is still not clear. This study was the first known investigation of the influence of statins on corneal specular microscopy (SM) and topography parameters.
METHODS: Thirty-four patients using a statin (atorvastatin) as hyperlipidemia treatment (Group 1) and 34 age- and sexmatched healthy subjects (Group 2) were prospectively included in the study. Demographic data and ophthalmic findings of participants were reported and analyzed. Cellular morphology was evaluated using the noncontact SM and corneal endothelial cell density (CECD) (cells/mm2), polymegathism (coefficient of variation in cell size [CV], %), and pleomorphism (% hexagonal cells [Hex]) data. Anterior chamber depth and volume, iridocorneal angle degree, average keratometry diopters were also measured with corneal topography.
RESULTS: The mean age was 53.03±7.23 years (range: 38–73 years) for Group 1 and 53.15±10.7 years (range: 34–80 years) for Group 2 (p=0.958). Group 1 consisted of 11 female and 23 male patients and Group 2 included 13 female and 21 male participants (p=0.798). The mean CECD density was significantly higher in Group 1 when compared with that of Group 2 (2544.34±244.76 cells/mm2 [range: 2126.60–3107.00 cells/mm2] vs 2404.53±285.46 cells/mm2 [range: 1839.80–2892.30 cells/mm2], p=0.034). There were no significant statistical differences in the CV and Hex values between the groups (p=0.450 and p=0.717, respectively). The corneal topographic measurements were also not significantly different.
DISCUSSION AND CONCLUSION: The findings of this study revealed higher CECD values in statin users. Statins may have beneficial effects on cornea morphology.

Keywords: Cornea, endothelial cell density specular microscopy, statin, topography

Bengi Ece Kurtul, Alparslan Kurtul, Kustharbek Ergashev. Is There a Relationship between Statin Use and Corneal Specular Microscopy and Topography Findings?. Beyoglu Eye J. 2021; 6(4): 280-284

Corresponding Author: Bengi Ece Kurtul, Türkiye
Manuscript Language: English
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