ISSN: 2459 - 1777 | E-ISSN 2587-0394
Volume : 6 Issue : 1 Year : 2021

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Beyoglu Eye Journal Effects of Topical Carbonic Anhydrase Inhibitors on the Olfactory Sense [Beyoglu Eye J]
Beyoglu Eye J. 2021; 6(1): 19-23 | DOI: 10.14744/bej.2021.27676

Effects of Topical Carbonic Anhydrase Inhibitors on the Olfactory Sense

Fatih Cem Gül1, Mete Güler2, Sabiha Güngör Kobat1, Sertaç Duzer3, Öner Sakallıoğlu3, Fatih Çelik1, Abdulvahap Akyiğit4
1Department of Ophthalmology, Health and Science University, Elazig Fethi Sekin City Hospital, Elazig, Turkey
2Department of Ophthalmology, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey
3Department of Ent, Health and Science University, Elazig Fethi Sekin City Hospital, Elazig, Turkey
4Department of ENT, Firat University, Elazig, Turkey

INTRODUCTION: The sense of smell plays an important role in daily life. Olfactory impairment can significantly affect an individual’s quality of life. Topical carbonic anhydrase inhibitors are commonly used to treat elevated intraocular pressure (IOP). One potential side effect of these drugs is a loss of the sense of smell. This study is an examination of changes in olfactory function in patients who used dorzolamide and brinzolamide to control IOP after a laser capsulotomy.
METHODS: A total of 60 patients with posterior capsule opacification were included in the study. Sniffin’ Sticks (Burghart Messtechnik GmbH, Wedel, Germany) were used to evaluate patient olfactory sensitivity before starting the topical treatment and after 1 week of treatment.
RESULTS: No statistically significant decrease in olfactory performance was observed in users of either brinzolamide or dorzolamide (p=0.705, p=0.405 respectively).
DISCUSSION AND CONCLUSION: No negative effect on the sense of smell was determined after 7 days of topical application of a carbonic anhydrase enzyme inhibitor to the eye in patients with no previous anosmia.

Keywords: Brinzolamide, dorzolamide, smell, Sniffin’ Sticks, treatment

Fatih Cem Gül, Mete Güler, Sabiha Güngör Kobat, Sertaç Duzer, Öner Sakallıoğlu, Fatih Çelik, Abdulvahap Akyiğit. Effects of Topical Carbonic Anhydrase Inhibitors on the Olfactory Sense. Beyoglu Eye J. 2021; 6(1): 19-23

Corresponding Author: Fatih Cem Gül, Türkiye
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