ISSN: 2459 - 1777 | E-ISSN 2587-0394
Volume : 7 Issue : 4 Year : 2022
Beyoglu Eye Journal Peripapillary Choroidal Vasculature in Pediatric Eyes with Type 1 Diabetes Mellitus [Beyoglu Eye J]
Beyoglu Eye J. 2022; 7(4): 291-297 | DOI: 10.14744/bej.2022.24471

Peripapillary Choroidal Vasculature in Pediatric Eyes with Type 1 Diabetes Mellitus

Murat Hasanreisoğlu1, Cem Kesim1, Nur Sena Uzunay3, Ayse Yildiz Tas2, Melisa Zisan Karslioglu1, Afsun Sahin2
1Department of Ophthalmology, Koc University Faculty of Medicine, Istanbul, Türkiye
2Koc University Research Centre For Translational Medicine, Istanbul, Türkiye
3Koc University Faculty of Medicine, Istanbul, Türkiye

OBJECTIVES: Choroidal vasculature change in children with diabetes mellitus is not investigated enough although it could reflect clinical outcome.
METHODS: Pediatric Type 1 diabetes mellitus (T1DM) patients and healthy controls were retrospectively evaluated. Peri-papillary retinal nerve fiber layer optical coherence tomography (OCT) images of the right eyes were analyzed. Choroidal parameters including total choroidal area, luminal area, stromal area, and choroidal vascularity index were measured through image binarization.
RESULTS: Twenty eyes of 20 patients were compared with 46 eyes of 46 healthy controls. Mean total choroidal area, luminal area, and stromal area were 1.59±0.35, 1.10±0.24, and 0.50±0.13 mm2 in patients’ eyes and 1.52±0.49, 1.05±0.34, and 0.47±0.17 mm2 in healthy eyes. No difference was found in choroidal vascularity indices between patients and healthy eyes (68.8±3.9% vs. 69.4±4.4%, p=0.521). Temporal choroidal vascularity index was significantly higher than its nasal counterpart in healthy eyes (71.8±5.0% vs. 68.6±4.9%, p<0.001) which was not significant in patients’ eyes (70.7±4.0% vs. 68.9±5.1%, p=0.067). Temporal quadrant had the highest choroidal vascularity index score among all quadrants in healthy controls (all p<0.05), whereas no choroidal vascularity index difference between quadrants was detected in patients (p=0.75).
DISCUSSION AND CONCLUSION: Peripapillary choroidal vasculature has shown subtle sectoral changes which did not reflect the overall peri-papillary OCT section in pediatric T1DM patients when compared with healthy controls.

Keywords: Peripapillary choroid, retinal vasculature, type 1 diabetes mellitus, vascularity.

Murat Hasanreisoğlu, Cem Kesim, Nur Sena Uzunay, Ayse Yildiz Tas, Melisa Zisan Karslioglu, Afsun Sahin. Peripapillary Choroidal Vasculature in Pediatric Eyes with Type 1 Diabetes Mellitus. Beyoglu Eye J. 2022; 7(4): 291-297

Corresponding Author: Murat Hasanreisoğlu, Türkiye
Manuscript Language: English
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