ISSN: 2459-1777 | E-ISSN 2587-0394
Volume : 8 Issue : 1 Year : 2023
Beyoglu Eye Journal Long-Term Clinical Results of Trabectome Surgery in Turkish Patients with Primary Open Angle Glaucoma and Pseudoexfoliative Glaucoma [Beyoglu Eye J]
Beyoglu Eye J. 2023; 8(1): 14-20 | DOI: 10.14744/bej.2023.13540

Long-Term Clinical Results of Trabectome Surgery in Turkish Patients with Primary Open Angle Glaucoma and Pseudoexfoliative Glaucoma

Yasemin Ün1, Cihan Büyükavşar2, Doğukan Cömerter3, Murat Sönmez3, Yıldıray Yıldırım4
1Department of Ophthalmology, Istanbul Haydarpaşa Numune Training and Research Hospital, Istanbul, Türkiye
2Department of Ophthalmology, Gemlik Atakent Medical Center, Bursa, Türkiye
3Department of Ophthalmology, Istanbul Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Türkiye
4Department of Ophthalmology, Freelance Physician

OBJECTIVES: The objectives of the study were to analyze the long-term results of trabectome surgery in Turkish patients with primary open angle glaucoma (POAG) and pseudoexfoliative glaucoma (PEXG) and to characterize the risk factors for failure.
METHODS: This single-center retrospective non-comparative study included 60 eyes of 51 patients diagnosed with POAG and PEXG, who underwent trabectome alone or phacotrabeculectomy (TP) surgery between 2012 and 2016. Surgical suc-cess was defined as a 20% decrease in intraocular pressure (IOP) or IOP≤21 mmHg and no further glaucoma surgery. Risk factors for further surgery were analyzed with the Cox proportional hazard ratio (HR) models. The cumulative success analysis was undertaken with the Kaplan–Meier method based on the time to further glaucoma surgery.
RESULTS: The mean follow-up period was 59.4±14.3 months. During the follow-up period, 12 eyes required additional glaucoma surgery. The mean pre-operative IOP was 26.9±6.8 mmHg. The mean IOP at the last visit was 18.8±4.7 mmHg (p<0.01). IOP decreased 30.1% from the baseline to the last visit. The average number of antiglaucomatous drug mole-cules used was 3.4±0.7 (range 1–4) preoperatively and 2.5±1.3 (range 0–4) at the last visit (p<0.01). The risk factors for further surgery requirement were determined as a higher baseline IOP value (HR: 1.11, p=0.03] and the use of a higher number of preoperative antiglaucomatous drug molecules (HR: 2.54, p=0.09). The cumulative probability of success was calculated as 94.6%, 90.1%, 85.7%, 82.1%, and 78.6% at three, 12, 24, 36, and 60 months, respectively.
DISCUSSION AND CONCLUSION: The success rate of trabectome was 67.3% at 59 months. A higher baseline IOP value and the use of a higher number of antiglaucomatous drug molecules were associated with an increased risk of further glaucoma surgery requirement.

Keywords: Ab interno trabeculectomy, intraocular pressure, open angle glaucoma, pseudoexfoliative glaucoma, trabectome

Yasemin Ün, Cihan Büyükavşar, Doğukan Cömerter, Murat Sönmez, Yıldıray Yıldırım. Long-Term Clinical Results of Trabectome Surgery in Turkish Patients with Primary Open Angle Glaucoma and Pseudoexfoliative Glaucoma. Beyoglu Eye J. 2023; 8(1): 14-20

Corresponding Author: Yasemin Ün, Türkiye
Manuscript Language: English
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