ISSN: 2459 - 1777 | E-ISSN 2587-0394
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Beyoglu Eye Journal The Effect of Cone Localization on Higher Order Aberrations After Corneal Crosslinking for Keratoconus [Beyoglu Eye J]
Beyoglu Eye J. 2021; 6(3): 206-211 | DOI: 10.14744/bej.2021.07088

The Effect of Cone Localization on Higher Order Aberrations After Corneal Crosslinking for Keratoconus

Nilay Kandemir Beşek, Gülay Yalçınkaya, Ahmet Kırgız, Fevziye Öndeş Yılmaz, Burçin Kepez Yıldız, Yusuf Yıldırım, Ahmet Demirok
Department of Ophthalmology, University of Health Sciences, Beyoglu Eye Training and Research Hospital, Istanbul, Turkey

INTRODUCTION: This study was designed to evaluate the effects of corneal collagen cross-linking (CXL) on topographic parameters, visual acuity, and corneal high-order aberrations according to the preoperative cone location in keratoconus.
METHODS: This retrospective study assessed patients with keratoconus who underwent CXL between March 2016 and February 2019. Patients with a history of corneal surgery, corneal hydrops, corneal scar tissue, delayed epithelial healing, and a corneal thickness of <400 μm were excluded. The included eyes were divided into 2 groups according to the preoperative cone location: maximum K in the central 3-mm optical zone (group 1) or the central 3-mm to 5-mm optical zone (group 2). The preoperative and postoperative 24-month, best-corrected visual acuity (BCVA), intraocular pressure, K max, symmetry index front, corneal thickness, and high order aberration findings were recorded.
RESULTS: The study included 67 eyes of 67 patients with keratoconus: 39 in group 1, and 28 in group 2. There were statistically significant differences between the groups in the preoperative BCVA values (p=0.04). There was no significant difference between the preoperative and postoperative mean K max between the 2 groups (p=0.08). The mean difference in corneal thickness between preoperative and postoperative measurements was significantly lower in group 2 than in group 1 (p=0.03). The preoperative and postoperative mean spherical aberration was significantly higher in group 1 than in group 2 (p=0.001 and p=0.005, respectively).
DISCUSSION AND CONCLUSION: The preoperative cone location in keratoconus may affect CXL outcomes. At the end of the second year, CXL was found to have a similar efficacy on visual acuity and keratometry parameters in the central and paracentral cone groups, and the recovery in terms of a spherical aberration among high-order aberrations after CXL in the central cone group was better than that of the paracentral cone group.

Keywords: Central cone, cone localization, crosslinking, high order aberrations, keratoconus

Nilay Kandemir Beşek, Gülay Yalçınkaya, Ahmet Kırgız, Fevziye Öndeş Yılmaz, Burçin Kepez Yıldız, Yusuf Yıldırım, Ahmet Demirok. The Effect of Cone Localization on Higher Order Aberrations After Corneal Crosslinking for Keratoconus. Beyoglu Eye J. 2021; 6(3): 206-211

Corresponding Author: Nilay Kandemir Beşek, Türkiye
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