ISSN: 2459-1777 | E-ISSN 2587-0394
Volume : 9 Issue : 1 Year : 2024
Evaluation of Systemic Endothelial Dysfunction in Retinal Vein Occlusions [Beyoglu Eye J]
Beyoglu Eye J. 2022; 7(2): 126-133 | DOI: 10.14744/bej.2022.44265

Evaluation of Systemic Endothelial Dysfunction in Retinal Vein Occlusions

Erdinc Bozkurt1, Türkhun Çetin2, Ibrahim Rencüzoğulları3
1Department of Ophthalmology, Kafkas University, Kars, Turkey
2Department of Radiology, Kafkas University, Kars, Turkey
3Department of Cardiology, Kafkas University, Kars, Turkey

INTRODUCTION: Our aim in this study was to evaluate the systemic endothelial dysfunction status and carotid intima-media thickness (CIMT) in patients with retinal vein occlusion (RVO).
METHODS: Seventy-six patients who presented to the clinic with the diagnosis of RVO and 76 age- and gender-matched healthy individuals without a RVO history were included in the study. The patients’ best-corrected visual acuity (BCVA) and central macular thickness (CMT) were measures, and diabetes, hypertension, hyperlipidemia, carotid artery disease, body mass index, and smoking histories were recorded. The endothelial function levels of the patients, pulse wave velocity (PWV), flow-mediated dilation (FMD), and CIMT were measured. Endothelial dysfunction was detected by applying the FMD technique to the brachial artery. CIMT was evaluated by B-mode ultrasonography. Serum hematological parameters were evaluated.
RESULTS: BCVA (logMAR) was 1.39±1.30 in patients with RVO and 0.028±1.22 in the control group (p<0.001). CMT was 588.76±104.02 µm in patients with RVO and 265.20±45.11 µm in the control group (p=0.001). Hypertension, diabetes, and hyperlipidemia were found to be significantly higher in patients with RVO (p-value 0.001, 0.002, and 0.001, respec-tively). There was a significant difference between the groups in terms of FMD, PWV, and CIMT (all of them, p<0.001).
DISCUSSION AND CONCLUSION: The deterioration of FMD and PWV, which are indicators of endothelial dysfunction in patients with RVO, suggests that systemic endothelial dysfunction may play a role in the pathogenesis of RVO. Comprehensive studies with more patient participation are needed.

Keywords: Carotid intima-media thickness, flow-mediated dilatation, pulse wave velocity, retinal vein occlusion, systemic endothelial dysfunction.

Erdinc Bozkurt, Türkhun Çetin, Ibrahim Rencüzoğulları. Evaluation of Systemic Endothelial Dysfunction in Retinal Vein Occlusions. Beyoglu Eye J. 2022; 7(2): 126-133

Corresponding Author: Erdinc Bozkurt, Türkiye
Manuscript Language: English
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