Beyoglu Eye J. 2020; 5(3): 214-218 | DOI: 10.14744/bej.2020.41275

Assessment of Plasma Thiol-disulfide Balance in Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma

Tamer Takmaz¹, Derya Yaman², Nilay Yuksel¹, Mücella Arýkan Yorgun¹, Almila Þenat³, Özcan Erel^4
1Department of Ophthalmology, Ankara City Hospital, Ankara, Turkey
²Department of Ophthalmology, Kaðýzman State Hospital, Kars, Turkey
³Department of Medical Biochemistry, Taksim Training and Research Hospital,Istanbul, Turkey
⁴Department of Medical Biochemistry, Ankara City Hospital, Ankara, Turkey

INTRODUCTION: The thiol-disulfide balance is very important in cellular events such as apoptosis and oxidative stress. This study is a comparison of plasma thiol-disulfide homeostasis in patients with pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG).
METHODS: Thirty-one patients with PEXS, 43 patients with PEXG, and 38 healthy controls were included in this prospective study. The plasma level of native thiol and disulfide were measured using a spectrophotometric assay and the native thiol/disulfide ratio was analyzed
RESULTS: The demographic characteristics of the 3 groups were similar (p>0.05). Statistically significant differences were observed in the plasma disulfide levels (21.6±7.3 µmol/L vs. 17.4±6.8 µmol/L) and the native thiol/disulfide ratio (22.9±9.1 vs. 29.9±14.7) between the PEXG group and the controls (p=0.03, p=0.02, respectively).
DISCUSSION AND CONCLUSION: Significant differences in the plasma levels of disulfide and the native thiol/disulfide ratio in PEXG patients indicated a breakdown of the thiol-disulfide circuits.

Keywords: Oxidative stress, pseudoexfoliation syndrome, pseudoexfoliation glaucoma, thiol-disulfide balance.

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