ISSN: 2459 - 1777 | E-ISSN 2587-0394
Assessment of plasma thiol-disulfide balance in pseudoexfoliation syndrome and pseudoexfoliation glaucoma [Beyoglu Eye J]
Beyoglu Eye J. Ahead of Print: BEJ-41275 | DOI: 10.14744/bej.2020.41275

Assessment of plasma thiol-disulfide balance in pseudoexfoliation syndrome and pseudoexfoliation glaucoma

Tamer Takmaz1, Derya Yaman2, Nilay Yuksel1, Mücella Arıkan Yorgun1, Almila Şenat3, Ozcan Erel4
1Ankara City Hospital, Department of Ophthalmology
2Kağızman State Hospital, Department of Ophthalmology
3Taksim Training and Research Hospital, Department of Medical Biochemistry
4Ankara City Hospital, Department of Medical Biochemistry

INTRODUCTION: Thiol-disulfide balance is of great importance in some cellular events such as apoptosis and oxidative stress. In this study, we compared plasma thiol disulfide balance in patients with pseudoexfoliation syndrome (PEXS) and pseudoexfoliation glaucoma (PEXG).
METHODS: Thirty-one patients with PEXS, 43 patients with PEXG and 38 healthy controls were included in this prospective study. Plasma native thiol and disulfide levels were measured using a spectrophotometric assay and native thiol/disulfide ratio was analyzed.
RESULTS: Demographic characteristics were similar in three groups (p> 0.05). Statistically significant differences were observed in plasma disulfide levels (21.6 ± 7.3 vs. 17.4 ± 6.8) and native thiol/disulfide ratio (22.9 ± 9.1 vs. 29.9 ± 14.7) between PEXG and controls (p= 0.03; p= 0.02, respectively).
DISCUSSION AND CONCLUSION: Significant differences in plasma disulfide levels and native thiol/disulfide ratio in PEXG indicate the breakdown of the thiol- disulfide circuits.

Keywords: Pseudoexfoliation Syndrome, Pseudoexfoliation Glaucoma, Thiol Disulfide Balance, Oxidative Stress



Corresponding Author: Tamer Takmaz, Türkiye
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