ISSN: 2459 - 1777 | E-ISSN 2587-0394
Volume : 6 Issue : 1 Year : 2021

Quick Search




Comparison of Six Methods of Central Corneal Thickness Measurement in Healthy Eyes [Beyoglu Eye J]
Beyoglu Eye J. 2021; 6(1): 7-13 | DOI: 10.14744/bej.2021.17894

Comparison of Six Methods of Central Corneal Thickness Measurement in Healthy Eyes

Turgay Uçak1, Erel İçel2, Nurdan Gamze Taşlı2, Yücel Karakurt2, Hayati Yılmaz3, Adem Uğurlu2, Mehmet Demir1
1Department of Ophthalmology, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey
2Department of Ophthalmology, Erzincan University, Faculty of Medicine, Erzincan, Turkey
3Department of Ophthalmology, Faculty of Medicine, Hitit University, Corum, Turkey

INTRODUCTION: Several methods of measuring central corneal thickness (CCT) have been compared, however, the data are still limited and conflicting. The aim of this study was to determine the agreement of CCT measurements performed in healthy eyes using ultrasound pachymetry (USP), non-contact tono/pachymetry, specular microscopy, biometry, Scheimpflug-based corneal topography, and optical coherence tomography (OCT).
METHODS: All of the participants underwent a complete ophthalmological examination. The CCT of all of the eyes included was measured using 6 different methods. The agreement between the methods was analyzed using the mean difference and Bland-Altman analysis based on a 95% limits of agreement.
RESULTS: A total of 64 patients with a mean age of 40.96±14.52 years (range: 20-78 years) were included in the study. The mean CCT value was 552.10±35.65 μm, 550.40±35.55 μm, 554.67±35.49 μm, 545.39±34.21 μm, 546.25±35.49 μm, and 552.64±33.59 μm using USP, non-contact tono/pachymetry, non-contact specular microscopy, biometry, Scheimpflug-based corneal topography, and OCT, respectively. The bias values determined by Bland-Altman plots were -1.70, -2.56, 6.71, 5.85, and -0.53 for tono/pachymetry, specular microscopy, biometry, topography, and OCT, respectively. OCT demonstrated the lowest bias compared to USP. The overall intraclass correlation coefficient was 0.961 (range: 0.945-0.974) with a 95% confidence interval.
DISCUSSION AND CONCLUSION: All of the CCT measurements obtained using non-contact tono/pachymetry, non-contact specular microscopy, biometry, Scheimpflug-based corneal topography, and OCT were consistent with the USP measurements of healthy controls. Larger prospective studies to determine the interchangeability of different methods for CCT measurements in pathological conditions are warranted.

Keywords: Biometry, central corneal thickness, corneal topography, pachymetry, specular microscopy

Turgay Uçak, Erel İçel, Nurdan Gamze Taşlı, Yücel Karakurt, Hayati Yılmaz, Adem Uğurlu, Mehmet Demir. Comparison of Six Methods of Central Corneal Thickness Measurement in Healthy Eyes. Beyoglu Eye J. 2021; 6(1): 7-13

Corresponding Author: Turgay Uçak, Türkiye
LookUs & Online Makale