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Evaluation of Peripapillary Microcirculation in Patients with Acromegaly
Mine Karahan1, Atılım Armağan Demirtaş2, Leyla Hazar1, Sedat Ava1, Zafer Pekkolay3, Uğur Keklikçi11Department of Ophthalmology, Dicle University Faculty of Medicine, Diyarbakır, Turkey2Department of Ophthalmology, Health Sciences University, Izmir Tepecik Training and Research Hospital, Izmir, Turkey
3Department of Endocrinology and Metabolism, Dicle University Faculty of Medicine, Diyarbakır, Turkey
INTRODUCTION: The aim of this study was to evaluate the radial peripapillary capillary (RPC) and the optic nerve head (ONH) perfusion of patients with acromegaly using optical coherence tomography angiography (OCTA).
METHODS: Twenty-four eyes of 24 acromegaly patients comprised the study group and 24 eyes of 24 healthy individuals were used as a control group. The ONH and RPC vascular density (VD) was measured for each patient using OCTA. The insulin-like growth factor 1 (IGF-1) levels were also recorded and compared.
RESULTS: The VD of the inferior nasal ONH and nasal RPC was significantly lower in the acromegaly group than in the control group (p=0.047 and p=0.001, respectively). There was a significant negative correlation between the VD of the superior nasal ONH and the IGF-1 level (r=-0.283, p=0.038).
DISCUSSION AND CONCLUSION: The ONH and RPC VD values measured using OCTA were segmentally different in the acromegaly group compared with those of the control group. This method of non-invasive quantitative analysis of retinal perfusion using OCTA may be useful for future studies involving patients with acromegaly.
Manuscript Language: English
