ISSN: 2459 - 1777 | E-ISSN 2587-0394
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Beyoglu Eye Journal The Effect of Long-Term Usage of Single-Agent Antiglaucomatous Drops with Different Preservatives on Cornea Biomechanics [Beyoglu Eye J]
Beyoglu Eye J. 2021; 6(1): 24-30 | DOI: 10.14744/bej.2021.76376

The Effect of Long-Term Usage of Single-Agent Antiglaucomatous Drops with Different Preservatives on Cornea Biomechanics

Gözde Aksoy Aydemir1, Gülizar Demirok2, Ümit Eksioğlu3, Mehmet Yakın2, Firdevs Örnek2
1Department of Ophthalmology, Adiyaman University Training and Research Hospital, Adiyaman, Turkey
2Department of Ophthalmology, Health Sciences University, Ankara Training and Research Hospital, Ankara, Turkey
3Department of Ophthalmology, Baskent University Ankara Hospital, Ankara, Turkey

INTRODUCTION: This study examined the effect of antiglaucomatous drops with different preservatives on corneal biomechanics using the ocular response analyzer (ORA) (Reichert Technologies, Inc., Depew, NY, USA).
METHODS: Patients using antiglaucomatous medical treatment containing a single agent combined with a preservative for at least 1 year who underwent a control examination between January and December 2017 at a glaucoma unit were included in this retrospective study. The patients were divided into 5 groups according to the antiglaucomatous agent and preservative ingredients. Measurements were taken with the ORA and compared with a control group.
RESULTS: A total of 83 eyes treated eyes were included and analyzed. Thirty-three eyes of 33 patients were treated with latanoprost+benzalkonium chloride (BAC), 17 eyes of 17 patients were treated with travoprost+polyquad, 7 eyes of 7 patients were treated with bimatoprost+BAC, 18 eyes of 18 patients were treated with brimonidine+purite, 8 eyes of 8 patients were treated with brimonidine+BAC. A control group of 23 eyes of 23 healthy patients was also assessed for comparison. A significant decrease in corneal hysteresis (CH) and corneal resistance factor (CRF) was seen in the patients using bimatoprost+BAC and brimonidine+BAC when compared with the control group. Evaluation of the bimatoprost+BAC group and the latanoprost+BAC group revealed that the CH and the CRF was significantly lower in the group using bimatoprost+BAC (p<0.01).
DISCUSSION AND CONCLUSION: It has been reported that CH is a more important prognostic marker than central corneal thickness in glaucoma patients. Loss of visual field progresses faster in eyes with a low CH. Both preservatives and the active antiglaucomatous agents in medications can affect CH. Variation in CH in patients using antiglaucomatous drops over a long period is important in both the progression and follow-up of the disease.

Keywords: Antiglaucomatous drops, benzalkonium chloride, cornea biomechanics, ocular response analyzer, polyquad, purite.

Gözde Aksoy Aydemir, Gülizar Demirok, Ümit Eksioğlu, Mehmet Yakın, Firdevs Örnek. The Effect of Long-Term Usage of Single-Agent Antiglaucomatous Drops with Different Preservatives on Cornea Biomechanics. Beyoglu Eye J. 2021; 6(1): 24-30

Corresponding Author: Gözde Aksoy Aydemir, Türkiye
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