Does Choroidal Thickness Change with Fluorescein or Indocyanine Retinal Angiography Procedures?

INTRODUCTION: This study was designed to examine effects of fundus fluorescein angiography (FFA) and indocyanine green angiography (ICGA) procedures on retinal and choroidal anatomy using optical coherence topography (OCT).
METHODS: Sixty eyes of 60 patients were included in this study. Patients who underwent FFA (14 females and 16 males) formed Group 1, and patients who underwent ICGA (17 females, 13 males) formed Group 2. After full ophthalmological examination, macular and choroidal thickness (CT) were measured via OCT. Approximately 15 to 20 minutes after dye was injected for angiography procedure, OCT scan was performed again. Statistical analyses were performed to compare measurements taken before and after procedure.
RESULTS: Mean age was 58.9±10.7 years (range: 42-82 years) in FFA group and 54.9±16.1 (range: 27-77 years) in ICGA group. Mean macular thickness was 339±78 μm before FFA and 339±72 after FFA (p=0.792). Mean macular thickness was 340±80 μm before ICGA and 341±73 μm after ICGA (p=0.571). Mean subfoveal CT was 275±36 μm before FFA and 271±31 μm after FFA (p=0.389). Mean subfoveal CT was 338±36 μm before ICGA and 366±38 μm after ICGA (p=0.022). There was significant increase in CT after ICGA procedure.
DISCUSSION AND CONCLUSION: CT may not change with FFA procedure, but may increase with ICGA procedure.