ISSN: 2459 - 1777 | E-ISSN 2587-0394
Beyoglu Eye Journal Effects of Topical Nepafenac and Fluorometholone on Macular Thickness After Posterior Capsulotomy Using Neodymium-doped Yttrium-Aluminum-Garnet Laser [Beyoglu Eye J]
Beyoglu Eye J. 2020; 5(2): 64-72 | DOI: 10.14744/bej.2020.96158

Effects of Topical Nepafenac and Fluorometholone on Macular Thickness After Posterior Capsulotomy Using Neodymium-doped Yttrium-Aluminum-Garnet Laser

Cemile Ucgul Atilgan1, Pinar Kosekahya1, Esat Yetkin1, Mehtap Caglayan2, Yasin Sakir Goker1, Selam Yekta Sendul3
1Department of Ophthalmology, Ulucanlar Goz Training and Research Hospital, Ankara, Turkey
2Department of Ophthalmology, Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey
3Department of Ophthalmology, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey

INTRODUCTION: The aim of this study was to assess the effects of topical 0.1% nepafenac and 0.1% fluorometholone on macular thickness (MT) after a neodymium: yttrium-aluminum-garnet (Nd: YAG) laser posterior capsulotomy and to compare the findings with those of untreated patients.
METHODS: This prospective study included 75 eyes of 75 patients with posterior capsule opacification. The patients were divided into 3 groups according to the medications administered after a capsulotomy procedure. Group 1 comprised 25 patients who were prescribed 0.1% nepafenac for a week, Group 2 consisted of 25 patients who were prescribed 0.1% fluorometholone for a week, and Group 3 consisted of 25 patients who were not prescribed any medication. A circular-shaped capsulotomy was performed in all cases. MT was measured before the capsulotomy and at the first day, first week, and first month after the procedure using spectral domain-optical coherence tomography and the change values were compared within and between groups.
RESULTS: In Group 1, the superior and nasal parafoveal MT, temporal, and nasal perifoveal MT values at the first month were statistically significantly greater than those observed in the first week (p<0.05 for all values). In Group 2, the superior and nasal parafoveal MT and inferior perifoveal MT measurements in the first month were greater than those recorded the first week (p<0.05 for all values). In Group 3, there was a gradual increase seen in the first day, first week, and first month in the superior and temporal parafoveal MT value (p<0.05 for all). The change value in the parafoveal temporal quadrant was significant between groups, indicating a greater increase in the untreated group compared with the nepafenac and fluorometholone groups (p=0.04).
DISCUSSION AND CONCLUSION: An increase in MT can occur after an Nd: YAG laser posterior capsulotomy. Both topical 0.1% nepafenac and 0.1% fluorometholone can prevent this increase. The 2 drugs were comparable; neither demonstrated apparent superiority to the other.

Keywords: Fluorometholone, macular thickness, Nd: YAG laser posterior capsulotomy, nepafenac, posterior capsule opacification.

Cemile Ucgul Atilgan, Pinar Kosekahya, Esat Yetkin, Mehtap Caglayan, Yasin Sakir Goker, Selam Yekta Sendul. Effects of Topical Nepafenac and Fluorometholone on Macular Thickness After Posterior Capsulotomy Using Neodymium-doped Yttrium-Aluminum-Garnet Laser. Beyoglu Eye J. 2020; 5(2): 64-72

Corresponding Author: Selam Yekta Sendul, Türkiye
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