ISSN: 2459 - 1777 | E-ISSN 2587-0394
Volume: 4
Issue: 1
Year: 2019
Macular choroidal thickness in patients with ocular hypertension as assessed by enhanced depth imaging optical coherence tomography [Beyoglu Eye J]
Beyoglu Eye J. Ahead of Print: BEJ-96268 | DOI: 10.14744/bej.2019.96268  

Macular choroidal thickness in patients with ocular hypertension as assessed by enhanced depth imaging optical coherence tomography

Pinar Topcu-Yilmaz, Ozlem Gürbüz Köz, Alper Yarangumeli, Mehmet Numan Alp
Health Sciences University, Ankara Numune Education and Research Hospital, Ankara, Turkey

INTRODUCTION: To evaluate the macular choroidal thickness (CT) in patients with ocular hypertension (OHT) using spectral domain optical coherence tomography (SD-OCT) and compare the results with healthy individuals.
METHODS: Thirty eyes of 30 patients newly diagnosed with OHT and 24 eyes of 24 healthy controls were included in this cross-sectional study. After a detailed ophthalmological examination; macular CT was measured with enhanced depth imaging optical coherence tomography (EDI-OCT) (Cirrus HD-OCT, Carl Zeiss Meditec) at the fovea and at positions 500 µ, 1000 µ, 1500 µ nasal and temporal to the fovea. Mann-Whitney U test was used to compare the CT measurements between the groups. The correlation between the mean deviation, pattern standart deviation and retinal nerve fiber layer thickness (RNFL) and CT was evaluated with Spearman correlation coefficient. Statistical significance was accepted as p< 0.05.
RESULTS: The average CT in the OHT group was significantly thinner than that of the controls at locations 1000 µ (250,13 ± 69.53µ vs 275,92 ± 47,34µ; p=0.02) and 1500 µ (236,03 ± 65,44 µ vs 265,46 ± 47,56µ; p=0.009) temporal to the fovea. The CT at the other measurement points was also thinner in eyes with OHT, but this difference failed to reach to a statistical significance. A moderately negative correlation was detected between the mean deviation and CT at locations 1000 µ (r=-0.42, p=0.03) and 1500 µ (r=-0.44, p=0.02) temporal to the fovea There was a moderate correlation between the average RNFL thickness and CT at locations 500 µ (r=0.44, p=0.03), 1000 µ (r=0.42, p=0.04) and 1500 µ (r=0.56, p=0.005) temporal to the fovea.
DISCUSSION AND CONCLUSION: In the present study; Macular CT was thinner in patients with OHT and this thinning was statistically significant at temporal macula. A longitudinal prospective study involving multiple EDI-OCT measurements is required to uncover the relationship.

Keywords: choroidal thickness, EDI-OCT, ocular hypertension, optical coherence tomography




Corresponding Author: Pinar Topcu-Yilmaz, Türkiye


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