INTRODUCTION: To evaluate relationships between macular choroidal thickness (mCT) and ocular parameters, such as optic nerve head (ONH) and multifocal electroretinogram (mf-ERG) parameters in cases with primary open-angle glaucoma (POAG).
METHODS: This controlled and prospective clinical trial included 49 patients with POAG diagnosed for the fırst time and 47 healthy participants. Macular CTs, ONH and mf-ERG parameters were measured, and the examination findings were recorded at baseline and follow-ups.
RESULTS: In the POAG group, the mean mCT was 254.92±37.65 μm at baseline, and it was 235.6±38.48 μm at 3-month and was 237.55±37.27 μm at 6-month. In the glaucoma group, there was a significant decrease in the first 3 months despite the treatment, but no significant change was observed in the next 3 months. In the healthy group, the mean mCTs were 287.78±26.77 μm, 285.48±25.58 μm and 285.02±27.44 μm at baseline, at 3-month and at 6-month, respectively. No significant change was observed in the control group throughout the process. However, the mean mCT values in the glaucoma group were significantly thinner in all controls compared to the healthy group (p<0.05). Furthermore, significant correlations were found between CT and some ONH as well as mf-ERG parameters.
DISCUSSION AND CONCLUSION: The choroid can play an important role in the pathogenesis of glaucoma. Significant correlations in parameters support this relationship. Moreover, we have observed that the glaucomatous effect initiated first in the inferior quadrant of ONH.