ISSN: 2459 - 1777 | E-ISSN 2587-0394
Volume: 4
Issue: 1
Year: 2019
The Optimal Cutoff Value of Neutrophil/Lymphocyte Ratio in Severe Grades of Diabetic Retinopathy Short Title: NLR in Diabetic Retinopathy [Beyoglu Eye J]
Beyoglu Eye J. Ahead of Print: BEJ-85698 | DOI: 10.14744/bej.2019.85698  

The Optimal Cutoff Value of Neutrophil/Lymphocyte Ratio in Severe Grades of Diabetic Retinopathy Short Title: NLR in Diabetic Retinopathy

Çağrı İlhan1, Mehmet CITIRIK2, Mehmet Murat Uzel3, KEMAL TEKIN4
1Department of Ophthalmology, Hatay State Hospital, Hatay, Turkey
2department of Ophthalmology, Ulucanlar Eye Research and Education Hospital, Ankara, Turkey
3department of Ophthalmology, Balikesir University, Balikesir, Turkey
4department of Ophthalmology, Ercis State Hospital, Van, Turkey

INTRODUCTION: Purpose: To define the optimal cutoff value of neutrophil/lymphocyte ratio (NLR) to predict the severe grades of diabetic retinopathy (DR).
METHODS: Methods: 40 patients with proliferative DR (PDR) and 40 patients with severe non-proliferative DR (NPDR) were included this prospective, case control study. Also, 35 age- and sex-matched healthy subjects were recruited for control group. The mean values of white blood cell (WBC) and rate of them were compared among groups.
RESULTS: Results: Groups were similar in terms of age and sex. Neutrophil, lymphocyte, monocyte, platelet counts, and main platelet volume (MPV) values were similar in 3 groups (all of p values >0.05). The mean NLR was 2.67 ± 1.02 in PDR, 2.16 ± 0.58 in severe NPDR, and 1.85 ± 0.49 in control groups and there was statistically significant difference between 3 groups (p=0.003). In post-hoc analysis, NLR of PDR and severe NPDR were statistically significant higher than control (p=0.002 and p=0.048 respectively), but there was no statistically significant difference between PDR and severe NPDR (p=0.083). Monocyte/lymphocyte, platelet/lymphocyte, and MPV/lymphocyte ratios were also similar in 3 groups (all of p values >0.05).
DISCUSSION AND CONCLUSION: Conclusion: The NLR value of 2.11 or higher predicted DR (included PDR and severe NPDR) with a sensitivity of 76% and specificity 80%.

Keywords: Neutrophil/lymphocyte ratio, proliferative diabetic retinopathy, severe nonproliferative diabetic retinopathy.




Corresponding Author: Çağrı İlhan, Türkiye


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