ISSN: 2459 - 1777 | E-ISSN 2587-0394
Inner Retinal Layer Disease: Multiple Sclerosis [Beyoglu Eye J]
Beyoglu Eye J. 2020; 5(2): 93-101 | DOI: 10.14744/bej.2020.65982

Inner Retinal Layer Disease: Multiple Sclerosis

Mehmet Cem Sabaner1, Resat Duman2, Rahmi Duman3, Ersan Cetinkaya4, Kenan Yigit4, Hayri Demirbas5
1Department of Ophthalmology, Bafra State Hospital, Samsun, Turkey
2Department of Ophthalmology, Bursa City Hospital, Bursa, Turkey
3Department of Ophthalmology, Liv Hospital, Ankara, Turkey
4Department of Ophthalmology, Sağlık Bilimleri University, Antalya Trainig and Research Hospital, Antalya, Turkey
5Department of Neurology, Afyonkarahisar Health Sciences University, Faculty of Medicine, Afyon, Turkey

INTRODUCTION: This study was an analysis of the retinal layer thickness in multiple sclerosis (MS) patients using spectral-domain optical coherence tomography (SD-OCT).
METHODS: A total of 42 patients diagnosed in the neurology clinic with MS according to the McDonald Criteria and 21 healthy individuals were included in the study and 4 groups were created. The first group comprised 21 eyes of 21 MS patients without eye involvement, the second group was made up of 21 eyes of 21 MS patients with a history of optic neuritis, the third group included the other eye of patients in the second group without a history of optic neuritis, and the fourth group was a control group of 21 eyes of 21 healthy individuals. SD-OCT was used to visualize and measure the retinal layers and the thickness was analyzed using the device software.
RESULTS: The mean age of the patient groups was 35.39±7.52 years, while it was 32.86±2.60 years in the control group. The mean duration of the disease was 9.81±6.65 years with a mean of 4.84±2.38 attacks. The ganglion cell layer (GCL) and the inner plexiform layer (IPL) of all of the patients were thinner compared with the control group in the parafoveal and perifoveal areas. All regions of the retinal nerve fiber layer (RNFL) of patients in the second group were thinner than those of the control group. The RNFL, GCL, and IPL in the central, parafoveal and perifoveal macular rings in group 3 were thinner than the group 1 measurements; however, this difference was not statistically significant. Although the RNFL, GCL, and IPL layer thicknesses were lower in group 2 than group 3, only the difference in the parafoveal GCL thickness was statistically significant.
DISCUSSION AND CONCLUSION: This study demonstrated that MS affects retinal layer thickness, and particularly the inner retinal layers.

Keywords: Multiple sclerosis, optical coherence tomography, optic neuritis.

Mehmet Cem Sabaner, Resat Duman, Rahmi Duman, Ersan Cetinkaya, Kenan Yigit, Hayri Demirbas. Inner Retinal Layer Disease: Multiple Sclerosis. Beyoglu Eye J. 2020; 5(2): 93-101

Corresponding Author: Mehmet Cem Sabaner, Türkiye
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