ISSN: 2459 - 1777 | E-ISSN 2587-0394
Volume: 4
Issue: 1
Year: 2019
Alterations in corneal biomechanical and topographic features after accelerated crosslinking: 1 year results [Beyoglu Eye J]
Beyoglu Eye J. Ahead of Print: BEJ-44154 | DOI: 10.14744/bej.2019.44154  

Alterations in corneal biomechanical and topographic features after accelerated crosslinking: 1 year results

Ahmet Kirgiz1, Sevil Karaman Erdur2, Kubra Serefoglu Cabuk1, Kursat Atalay3, Şenay Aşık Nacaroğlu3
1University of Health Sciences, Prof. Dr. N.Resat Belger Beyoglu Eye Training and Research Hospital, Istanbul, Turkey
2Department of Opthalmology, Istanbul Medipol University, Istanbul, Turkey
3University of Health Sciences, Bagcilar Training and Research Hospital, Istanbul, Turkey

INTRODUCTION: To determine the biomechanical and topographic alterations within first year after accelerated crosslinking (CXL) treatment in patients with keratoconus.
METHODS: In this prospective study, 52 eyes of 52 patients with progressive keratoconus underwent accelerated CXL were included. All patients had a detailed preoperative ophthalmologic examination including slit-lamp evaluation, Goldmann tonometry, fundoscopy, topography by Scheimpflug imaging (Sirius), and corneal biomechanical evaluation with a biomechanical waveform analysis device (ORA). Alterations in visual acuity and topographic findings were evaluated before treatment and at 12 months follow-up. Corneal biomechanical features were obtained before treatment, and at 1st, 3rd, 6th and 12th months.
RESULTS: Uncorrected-visual acuity and best-corrected visual acuity both statistically significantly improved at 12th month (p=0.001). There were no statistically significant differences in keratometry values, whereas maximum K (AKfront) and symmetry index front (SIfront) decreased significantly (p=0.015 and p=0.009, respectively). Moreover, corneal thinnest point and volume also decreased significantly at 12th month (p=0.001 for both). Goldmann-correlated intraocular pressure (IOPg) and corneal compensated IOP (IOPcc) values transiently increased in first 3 months, while corneal hysteresis (CH) and corneal resistance factor (CRF) transiently decreased, with the difference not statistically significant (p>0.05). However, central corneal thickness significantly decreased at the end of 12th month (p=0.001).
DISCUSSION AND CONCLUSION: Accelerated CXL seems to be effective in stopping the progression of keratoconus. Our findings showed transient alterations in biomechanical features which will end with the preoperative values at the end of the 12th month. Further studies are needed to demonstrate the changes in corneal biomechanics in vivo.

Keywords: corneal biomechanics, corneal topography, accelerated crosslinking, keratoconus, corneal hysteresis

Corresponding Author: Ahmet Kirgiz, Türkiye

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