ISSN: 2459 - 1777 | E-ISSN 2587-0394
Volume: 3
Issue: 3
Year: 2018
Duane Retraction Syndrome and Accompanying Ocular Abnormalities [Beyoglu Eye J]
Beyoglu Eye J. Ahead of Print: BEJ-36854 | DOI: 10.14744/bej.2019.36854  

Duane Retraction Syndrome and Accompanying Ocular Abnormalities

Murat Kocamaz1, Ebru Demet Aygıt2, Aslı İnal2, Osman Bulut Ocak2, Uğur Çiçek3, Birsen Gokyigit2
1Department of Ophthalmology, Darıca Farabi Training and Research Hospital, Darıca/Kocaeli, Turkey
2University of Healty Sciences, Prof. Dr. N. Resat Belger Beyoglu Eye Training and Research Hospital, Istanbul, Turkey
3Department of Ophthalmology, Siirt State Hospital, Siirt, Turkey

INTRODUCTION: Duane Retraction Syndrome (DRS) is a congenital syndrome that is characterized by adduction and/or abduction limitation in eye movements, narrowing of palpebral fissure in adduction with or without glob retraction and up/downshoot. It was first described by Stilling and Turk. Alexander Duane published a series of 54 cases in 1905 and the syndrome was called as Duane Syndrome. In recent classifications, Duane Syndrome has been identified as a part of the congenital cranial dysinnervation disorders (CCDD). These disorders contain congenital, non-progressive, sporadic or familial neuromuscular diseases.
Several systemic abnormalities, syndromes and ocular additional findings can accompany DRS. In this study, we aimed to evaluate the additional eye findings in patients with DRS.

METHODS: 632 patients with DRS who were followed from 1995 to 2016 were reviewed retrospectively. Patients with a follow-up of less than six months and patients with a history of eye/cranial trauma or injury were not included in the study. Before all patients were examined, detailed anamnesis was obtained and all medical records and additional systemic diseases were interrogated.
RESULTS: The average of follow-up time of 632 patients was 45 months ( min: 6 months max: 128 months). There were 255 male and 377 female patients. 34 patients (5.4%) had ocular extra abnormalities. The most frequently associated ocular pathologies with DRS were congenital ptosis (in 6 patients- 0.94%) and coloboma of iris (in 4 patients- 0.63%).
DISCUSSION AND CONCLUSION: Most cases of Duane Syndrome are observed as isolated. However, various ocular and systemic abnormalities and syndromes are associated with DRS. In particular, synkinetic syndromes can be frequently observed together with DRS. Therefore, complete ocular examination and anamnesis are crucial in cases with DRS.

Keywords: Congenital ptosis, Duane Retraction Syndrome, iris coloboma, nystagmus.

Corresponding Author: Murat Kocamaz, Türkiye

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